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Nanny G is Frasier's first wife and a well-known children's entertainer, in the style of Raffi. She first appeared in the tenth season episode of Cheers, titled "One Hugs, the Other Doesn't", played by Emma Thompson. She then appeared in the Frasier Season 9 premiere episode "Don Juan in Hell" in a fantasy sequence as a young hippie from Frasier's memory (played by Dina Spybey). Her final appearance was in the final season of Frasier in the episode "Caught in the Act," this time played by Laurie Metcalf, who proclaims, "Do you have any idea what it’s like to play the same character for twenty years?!" - an in-joke reference to Grammer's own twenty-year portrayal of Frasier Crane on Cheers and Frasier. Frasier and Nanette were briefly married while he was an undergraduate; the ceremony occurred at City Hall. The two experienced a strong sexual chemistry but Frasier claims that the marriage could not work because of their youth and naïveté.

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